The Vitamins +
Antioxidants Blend

While working in the hospital, unlike my peers - I rarely get sick. I credit that in large part to consistent supplementation with Vitamin C, D, and Zinc. That’s why Elixir is formulated with these key immune-boosting essentials, so you can stay strong and resilient no matter what comes your way.

Studies show that Vitamin C supports immune defense by strengthening barriers against infection, while Vitamin D and Zinc play crucial roles in regulating immune function. With Elixir, you’re not just staying hydrated—you’re fueling your body with what it needs to thrive.

Vitamin D

Depression

Kaviani et al. (2022)

Conducted an 8-week double-blind randomized clinical trial involving 56 patients with mild to moderate depression. The intervention group received 50,000 IU of cholecalciferol biweekly, while the control group received a placebo. The study found a significant increase in serum 25(OH)D levels and a significant decrease in depression severity as measured by the Beck Depression Inventory-II (BDI-II) in the vitamin D group compared to the placebo group. This suggests that vitamin D supplementation can effectively reduce depressive symptoms in this population. 

Srifuengfung et al. (2023)

Performed a systematic review and meta-analysis of 18 randomized controlled trials with a total of 1980 participants. The analysis demonstrated that vitamin D supplementation was significantly superior to placebo in reducing depressive symptoms, with a standardized mean difference of -0.49. The study also noted that vitamin D administered as bolus doses (oral intermittent high doses or intramuscular single high dose) appeared to be more effective than daily oral doses. This meta-analysis supports the efficacy of vitamin D in alleviating depressive symptoms, particularly in adults. 

Infection

Martineau et al. (2017) 

Conducted a systematic review and meta-analysis of individual participant data from 25 randomized controlled trials involving 11,321 participants. The study found that vitamin D supplementation significantly reduced the risk of acute respiratory tract infections (ARTIs) with an adjusted odds ratio (aOR) of 0.88 (95% CI, 0.81 to 0.96). The protective effect was more pronounced in individuals receiving daily or weekly vitamin D without additional bolus doses (aOR 0.81, 95% CI, 0.72 to 0.91) and in those with baseline 25-hydroxyvitamin D levels below 25 nmol/L (aOR 0.30, 95% CI, 0.17 to 0.53). 

Jolliffe et al. (2021) 

Performed a systematic review and meta-analysis of aggregate data from 46 randomized controlled trials with 75,541 participants. The study demonstrated that vitamin D supplementation reduced the risk of having one or more acute respiratory infections, with an odds ratio (OR) of 0.92 (95% CI, 0.86 to 0.99). The protective effect was particularly significant in trials where vitamin D was administered daily at doses of 400-1000 IU (OR 0.70, 95% CI, 0.55 to 0.89) and in participants aged 1-15 years (OR 0.71, 95% CI, 0.57 to 0.90). 

Bone Health

Tang et al. (2007)

Included 29 randomized trials with 63,897 participants aged 50 years or older. This study demonstrated that calcium, or calcium in combination with vitamin D, was associated with a 12% risk reduction in fractures of all types (RR 0.88, 95% CI 0.83-0.95) and a reduced rate of bone loss at the hip (0.54%, 95% CI 0.35-0.73) and spine (1.19%, 95% CI 0.76-1.61). The study recommended minimum doses of 1200 mg of calcium and 800 IU of vitamin D for optimal therapeutic effect.

ingredients Studies

  • 01

  • Effects of Vitamin D Supplementation on Depression and Some Selected Pro-Inflammatory Biomarkers: A Double-Blind Randomized Clinical Trial.

    Kaviani M, Nikooyeh B, Etesam F, et al. 

    BMC Psychiatry. 2022;22(1):694.

    doi:10.1186/s12888-022-04305-3. 

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  • 02

  • Efficacy and acceptability of vitamin D supplements for depressed patients: A systematic review and meta-analysis of randomized controlled trials

    Srifuengfung M, Srifuengfung S, Pummangura C, et al. 

    Nutrition (Burbank, Los Angeles County, Calif.). 2023;108:111968.

    doi:10.1016/j.nut.2022.111968. 

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  • 03

  • Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

    Martineau AR, Jolliffe DA, Hooper RL, et al. 

    BMJ (Clinical Research Ed.). 2017;356:i6583.

    doi:10.1136/bmj.i6583. 

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  • 04

  • Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

    Jolliffe DA, Camargo CA, Sluyter JD, et al. 

    The Lancet. Diabetes & Endocrinology. 2021;9(5):276-292.

    doi:10.1016/S2213-8587(21)00051-6. 

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  • 05

  • Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis

    Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A. 

    Lancet (London, England). 2007;370(9588):657-66.

    doi:10.1016/S0140-6736(07)61342-7

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Zinc and Vitamin C

Prasad et al. (2007) 

Conducted a randomized, double-blind, placebo-controlled trial in elderly subjects aged 55-87 years. The study found that zinc for 12 months significantly reduced the incidence of infections. The zinc-supplemented group had lower levels of inflammatory cytokines and oxidative stress markers compared to the placebo group, indicating an enhanced immune response and reduced infection rates. 

Polidori et al. (2004)

Assessed the effects of both short-term and long-term vitamin C supplementation on plasma antioxidant status and resistance to oxidative stress. The study found that vitamin C supplementation dose-dependently increased plasma ascorbate concentrations and enhanced the resistance of plasma to lipid peroxidation ex vivo, indicating significant antioxidant effects. 

 

Johnston et al. (2014)

This randomized controlled trial demonstrated that daily supplementation with 1000 mg of vitamin C significantly reduced the incidence and duration of colds. The study found a 45% reduction in the number of participants reporting cold episodes and a 59% reduction in cold duration in the vitamin C group compared to the placebo group. 

ingredients Studies

  • 01

  • Zinc Supplementation Decreases Incidence of Infections in the Elderly: Effect of Zinc on Generation of Cytokines and Oxidative Stress.

    Prasad AS, Beck FW, Bao B, et al. 

    The American Journal of Clinical Nutrition. 2007;85(3):837-44.

    doi:10.1093/ajcn/85.3.837. 

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  • 02

  • Short-term and long-term vitamin C supplementation in humans dose-dependently increases the resistance of plasma to ex vivo lipid peroxidation

    Polidori MC, Mecocci P, Levine M, Frei B. 

    Archives of Biochemistry and Biophysics. 2004;423(1):109-15.

    doi:10.1016/j.abb.2003.12.019. 

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  • 03

  • Vitamin C Supplementation Slightly Improves Physical Activity Levels and Reduces Cold Incidence in Men With Marginal Vitamin C Status: A Randomized Controlled Trial.

    Johnston CS, Barkyoumb GM, Schumacher SS. 

    Nutrients. 2014;6(7):2572-83.

    doi:10.3390/nu6072572. 

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